Sex linked inheritance in man: Theory and principles

Date: May 18, 2015

Sex linked inheritance Genes X-linked Y-linked inheritance colorblindness

Sex linked inheritance in man: Theory and principles

What is Sex linked inheritance: The inheritance of X-linked is called Sex linked inheritance. In humans, Males carry XY and females carry XX chromosomes. Thus, any mutation or deformity occurring in males will be carried as twice in the next female generations. This may or may not be carried to the next generations.

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Types of Sex linked inheritance:

X-linked inheritance: performed by those genes which are localized in the non-homologous sections of X-chromosome and have no corresponding allele on the Y- chromosome. X-linked genes are commonly known as Sex-linked genes. A recessive X-linked gene typically has a characteristic pattern called criss-cross inheritance. In which, X-linked recessive gene is transmitted from P1male parent (father) to F1 male progeny (grandsons) through its F1 heterozygous females (daughters). Example is Colorblindness.

Y-linked inheritance: performed by those genes which are localized in the non-homologous sections of Y-chromosome and have no corresponding allele on the X- chromosome. Y-linked genes are commonly known as holandric genes. Since, the Y-chromosome is small and does not contain many genes, few traits are Y-linked, and Y-linked diseases are rare. Since the only humans who have a Y chromosome are males, Y-linked traits are passed only from father to son, with no interchromosomal genetic recombination. Example of a holandric gene is: TSPY (testis-specific protein) gene, causing infertility in males.

X-Y linked inheritance: performed by those genes which are localized in homologous sections of X and Y chromosomes.

 

 


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